Richard Mayer has written a new article in Medical Education about applying the fundamentals of cognitive design to multimedia or online medical education. We know a lot about how to structure instruction to help people learn and Mayer's article is a very good introduction for people interested in learning more about how to do it. Mayer's writing has influence a lot of good multimedia design and his recommendations are all based on careful research.
Principles for instructional design include reducing the amount of extraneous cognitive processing (that is, processing that isn't related to the learning task), principles for managing essential processing (that is, processing that is related to the learning task), and principles for fostering generative processing.
These principles are probably best used for relative novices, or for an introduction to a subject but understanding these principles can help you develop online learning and even PowerPoint presentations.
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